Back to All Articles

When it comes to keeping our mouths clean and breath fresh, brushing and flossing alone doesn't always cut it. This is where mouthwash steps in, acting as a trusty sidekick in our oral health regimen. With its ability to reach hard-to-brush areas, mouthwash effectively reduces the risk of cavities and gum disease, giving us the confidence to flash our smiles. But with so many mouthwash options on the market, how do we decide which one is the best for us?

We'll be focusing on two options in this blog post: Twice Oral Wellness Immunity Rinse and LISTERINE® Antiseptic Mouthwash. These two products, while both aimed at promoting oral health, have distinct features and benefits that cater to different needs and preferences.

Twice Oral Wellness Immunity Rinse vs. LISTERINE® Antiseptic Mouthwash

LISTERINE® Antiseptic Mouthwash

Twice Oral Wellness Immunity Rinse

Main Ingredients

Eucalyptol, Menthol, Methyl Salicylate, Thymol, Alcohol

Colloidal Silver, Zinc, Hydrogen Peroxide, Baking Soda, Aloe Vera, Coconut Oil, Spirulina


Destroys plaque, Reduces gingivitis, Kills germs causing bad breath

Enhances natural defenses, supports healthy oral microbiome, soothes minor oral wounds, fights bad breath and plaque


Strong, medicinal

Mild, minty with a hint of spice

Alcohol Content

21.6% v/v



Traditional, transparent bottle with screw-on cap

Sleek, travel-friendly bottle with pressable nozzle


1L/~33 oz bottle lasts approx. 25 days

~100 mL/3.4 oz bottle lasts up to 30 days


LISTERINE® Antiseptic Mouthwash relies heavily on the power of essential oils. These oils, including eucalyptol, menthol, methyl salicylate and thymol, are derived from botanical sources and have been clinically proven to be effective in killing germs that cause plaque, gingivitis and bad breath.1 It also contains alcohol, which helps dissolve essential oils and kills bacteria in the mouth.2 Benzoic acid and sodium benzoate also aid in preventing microbial growth and help adjust the pH of the product. Additional ingredients such as Poloxamer 407 aid in mixing the oils and water and help remove food particles and debris. The product also contains various dyes for color, such as Green 3, Yellow 10 and Caramel.

Twice Oral Wellness Immunity Rinse is rich in ingredients like colloidal silver, known for reducing biofilm buildup,3 and zinc, which combats bad breath,4 plaque5 and calculus.6 The addition of hydrogen peroxide helps combat the growth of harmful bacteria7 while also contributing to whiten teeth.8 Baking soda, another key component, balances oral pH and neutralizes bad bacteria for a balanced microbiome,9 along with aiding in teeth whitening.10 Aloe vera helps soothe gum irritation and inflammation,11 while coconut oil fights bad breath by reducing harmful oral bacteria.12 Lastly, spirulina reduces dental plaque and inflammation.13 The omission of alcohol, SLS/SLES, parabens, gluten, BPA, animal products and artificial dyes in the formula makes this rinse a great option for those seeking a more natural, gentle oral care solution.

Ingredients Key Takeaways


  • Contains essential oils (Eucalyptol, Menthol, Methyl Salicylate, and Thymol), Alcohol, Benzoic Acid, Sodium Benzoate, Poloxamer 407 and coloring.

Twice Mouthwash:

  • Contains natural ingredients like Colloidal Silver, Zinc, Aloe Vera and Coconut Oil
  • Excludes alcohol, SLS/SLES, parabens, gluten, BPA, animal products and artificial dyes

Uses and Benefits

LISTERINE® Antiseptic Mouthwash has a proven track record in promoting oral health. They recommend rinsing for 30 seconds twice a day for 24-hour protection against the germs that cause bad breath, plaque and gum disease. It claims to reduce plaque by 52% and reduce gingivitis more effectively than merely brushing and flossing alone.14 These benefits make LISTERINE® a solid choice for those seeking a rigorous and effective oral care regimen.

On the other hand, Twice Oral Wellness Immunity Rinse is designed not only to promote general oral health but also to enhance your mouth's natural defenses and support a balanced and healthy oral microbiome. Twice suggests rinsing for 15 seconds after brushing twice a day and after meals. It protects against harmful bacteria and viruses and can also be used temporarily to cleanse minor oral wounds and canker sores without drying or irritation. With no alcohol, dye or artificial flavoring, this rinse offers a safe and natural oral care experience.

Benefits Key Takeaways

LISTERINE® Mouthwash:

  • Clinically proven 24-hour protection against germs causing bad breath, plaque and gum disease
  • Reduces plaque by 52% and reduces gingivitis by 21% more than just brushing and flossing

Twice Mouthwash:

  • Enhances natural defenses and supports a healthy oral microbiome
  • Protects against harmful bacteria and viruses
  • Can cleanse minor oral wounds and canker sores without drying or irritation


LISTERINE® Antiseptic Mouthwash is known for its bold, intense flavor. It contains essential oils like Eucalyptol, Menthol, Methyl Salicylate and Thymol, which together create a strong, somewhat medicinal taste that many associate with a clean, fresh mouth. It's worth noting that the flavor might not be everyone's cup of tea, but those who appreciate a strong, minty experience are likely to enjoy it.

Twice Oral Wellness Immunity Rinse aims to deliver a milder, more natural flavor. It contains Peppermint Oil and Extract, which provide a clean, crisp and refreshing minty taste. It also includes Cinnamomum Zeylanicum Bark Extract, which adds a hint of warming, slightly sweet spice to the mix. These ingredients, combined with others like Coconut Oil and Aloe Vera, result in a flavor profile that's balanced and pleasant without being overpoweringly minty or artificially sweet.

Flavor Key Takeaways

LISTERINE® Mouthwash:

  • Bold, intense, and somewhat medicinal flavor
  • Strong, refreshing and invigorating mouthfeel

Twice Mouthwash:

  • Mild, natural flavor
  • Balanced taste, not overpoweringly minty or artificially sweet

Alcohol Content

LISTERINE® Antiseptic Mouthwash contains alcohol at a concentration of 21.6% v/v. This relatively high alcohol content is one of the key factors behind the mouthwash's powerful germ-killing capabilities. Alcohol assists in dissolving essential oils, which are the primary active ingredients and contributes to the feeling of LISTERINE® working. However, it's also what gives LISTERINE® its somewhat intense, burning sensation — a feeling some users may find a little too strong. It's worth noting that alcohol-based mouthwashes may not be suitable for individuals who have a dry mouth or are sensitive to alcohol.

Twice Oral Wellness Immunity Rinse is entirely alcohol-free, making it a gentler option suitable for those who find the burn of alcohol-based mouthwashes uncomfortable or who are looking for a more natural oral care solution. An alcohol-free formulation can be beneficial for those who suffer from dry mouth, as alcohol can exacerbate dryness. Instead of alcohol, Twice Rinse relies on a blend of natural ingredients to fight bacteria, maintain oral pH and freshen your breath, resulting in a more comfortable rinse experience.

Alcohol Content Key Takeaways

LISTERINE® Mouthwash:

  • Contains 21.6% v/v alcohol
  • Potent germ-killing ability, but may not be suitable for individuals with dry mouth or alcohol sensitivity.

Twice Mouthwash:

  • Alcohol-free
  • Suitable for individuals with dry mouth or those seeking a natural oral care solution


LISTERINE® Antiseptic Mouthwash comes in a transparent, classic-shaped bottle with a secure, screw-on cap that doubles as a measuring cup for dosage. The bottle design is straightforward and functional, ensuring you can easily see how much product is left. However, due to its size and shape, it might not be the most travel-friendly option.

Twice Oral Wellness Immunity Rinse offers a sleek, modern approach to packaging. It comes in a non-transparent, travel-friendly bottle design, making it ideal for on-the-go oral care. The dual-action formula means the product is separated into two parts, requiring you to shake before use. The bottle features a pressable nozzle for dispensing the product directly into the mouth, an innovation that adds to the convenience and hygiene of use. And coming in at 3.4 oz, the bottle adheres to TSA guidelines for easy travel.

Packaging Key Takeaways

LISTERINE® Mouthwash:

  • Transparent, classic-shaped bottle with a measuring cap
  • Not particularly travel-friendly due to size

Twice Mouthwash:

  • Non-transparent, travel-friendly bottle
  • Features a pressable nozzle for direct dispensing


LISTERINE® Antiseptic Mouthwash is a widely recognized and accessible product, often available at an affordable price point, making it a solid choice for those on a budget. Its recommended usage of 20 ml twice daily means that a standard 1-liter bottle will last for about 25 days.

The strong antiseptic and anti-plaque benefits that LISTERINE® delivers ensure you're getting good value for your money, especially considering its clinical proof of reducing more plaque than just brushing and flossing alone.

Twice Oral Wellness Immunity Rinse might appear more expensive at first glance, but its value proposition goes beyond just the cost. This 3.4 oz mouthwash boasts a dual-action formula that’s designed to last up to five times longer than a standard 16-oz mouthwash, thanks to its advanced nano-emulsion technology. This means that a single bottle provides a one-month supply.

The unique blend of ingredients offers enhanced natural oral defenses, supporting a healthy oral microbiome and providing lasting freshness. All of these factors, combined with its convenient and recyclable packaging, make Twice Rinse a worthwhile investment for those seeking a high-performing, long-lasting and wellness-focused oral care product

Value Key Takeaways

LISTERINE® Mouthwash:

  • Accessible and affordable
  • Lasts about 25 days when used as directed
  • Clinically proven strong antiseptic and anti-plaque benefits

Twice Mouthwash:

  • More expensive but offers enhanced value through advanced technology
  • Lasts for 30 days when used as directed
  • Supports natural defenses, maintains a healthy oral microbiome and offers lasting freshness
A Twice Oral Wellness Immunity Rinse bottle next to the text "Oral Wellness Immunity Rinse. Natural Protection. Mouth Body Balance. Mineral Enriched. Full-Mouth Freshness. Plant-Based Clean.

    The Bottom Line

    When it comes to choosing a mouthwash, both LISTERINE® Antiseptic Mouthwash and Twice Oral Wellness Immunity Rinse have their strengths. It ultimately comes down to your personal needs, preferences and oral health goals.

    We hope this comparison helps you to make an informed choice that aligns with your lifestyle and oral care needs. Remember, a good oral care routine isn't just about choosing the right products — it's also about consistency. So, whichever mouthwash you decide on, make sure to use it regularly as part of a comprehensive oral hygiene routine.

    Shop Oral Wellness Immunity Rinse

    This page was written or reviewed for accuracy by the Twice Team. Learn more about us.


    1. The Journal of Clinical Dentistry - In vivo antimicrobial activity of an essential oil-containing mouthrinse on interproximal plaque bacteria
    2. The Bulletin of Tokyo Dental College - The efficacy of antimicrobial mouth rinses in oral health care
    3. ACS Applied Materials & Interfaces - Taking the Silver Bullet Colloidal Silver Particles for the Topical Treatment of Biofilm-Related Infections
    4. Journal of Applied Oral Science - Two mechanisms of oral malodor inhibition by zinc ions
    5. Compendium of Continuing Education in Dentistry - Antiplaque/antigingivitis efficacy and safety of a cetylpyridinium chloride/zinc gluconate mucoadhesive gel. Results of a 6-month clinical trial
    6. The Journal of Clinical Dentistry - Anticalculus effect of a cetylpyridinium chloride/zinc gluconate mucoadhesive gel: results of a randomized, double-blind, controlled clinical trial
    7. International Journal of Dentistry - A Systematic Review of the Effect of Oral Rinsing with H2O2 on Clinical and Microbiological Parameters Related to Plaque, Gingivitis, and Microbes
    8. Operative Dentistry - Efficacy of mouth rinses and toothpaste on tooth whitening
    9. National Journal of Maxillofacial Surgery - The effect of sodium bicarbonate oral rinse on salivary pH and oral microflora: A prospective cohort study
    10. The Journal of Clinical Dentistry - Laboratory assessment of tooth whitening by sodium bicarbonate dentifrices
    11. Journal of Indian Society of Periodontology - Aloe vera: It's effect on gingivitis
    12. Nigerian Medical Journal - Effect of coconut oil in plaque related gingivitis — A preliminary report
    13. International Journal of Pharmacy and Pharmaceutical Sciences - Effectiveness of spirulina mouthwash on reduction of dental plaque and gingivitis: a clinical study
    14. Journal of Dental Hygiene - Efficacy of Flossing and Mouthrinsing Regimens on Plaque and Gingivitis: A randomized clinical trial